Original Research Article I Volume 4 I Issue 3 I 2018
Synthesis of Thiosemicarbazones Derivatives and their in vitro Antioxidant Activity
Laxmi Manasa Chilakamari
The American Journal of Science and Medical Research; 4(3); 12-15
DOI:http://dx.doi.org/10.17812/ajsmr433
Abstract:
Thiosemicarbazones were reported to have antineoplastic, antibacterial, antiviral, antifungal, antimalarial, nueroprotective, antitubercular activities. This study aimed to synthesis of Thiosemicarbazones and evaluation for its antioxidant activities.The two derivatives of thiosemicarbazones are synthesized by using a conventional one step processes in which the respective halo-substituted acetophenones are condensed with thiosemicarbazide to result in the formation of the product.The structures of thiosemicarbazones were confirmed by spectroscopic (IR, 1H NMR, 13C NMR and MS) method. The antioxidant activity of these thiosemicarbazones was evaluated, in vitro and it’s shown that some of these compounds had significant antioxidant activity.
Keywords:
Thiosemicarboazones, antioxidant, NMR, MS
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Article Dates:
Received: 21 August 2018 ; Accepted: 24 September 2018; Published: 30 September 2018
How To Cite:
http://dx.doi.org/10.17812/ajsmr433 Received :21August, 2018 Accepted; 24September, 2018 Available online :30September, 2018
