Original Research Article I Volume 4 I Issue 1 I 2018
Evaluation of Oxidative DNA Damage in Gingival Epithelial Cells of Patients with Oral Sub Mucous Fibrosis
V. Sreedevi, S. Sunayana Begum, M. Manjula
The American Journal Science and Medical Research; 4(1); 26-29
DOI:http://dx.doi.org/10.17812/ajsmr4106
Abstract:
Objective: The study was undertaken to determine oxidative DNA damage and free radical levels in patients with oral submucous fibrosis. Methods: The DNA damage was evaluated using comet assay and free radicals including nitric oxide and malondialdehyde levels were estimated using biochemical methods. Statistical analysis was performed using student t-test. Results: Comet assay revealed an increased frequency of comets in patients when compared to controls. The mean levels of nitric oxide and lipid peroxidation were significantly increased in patients when compared to controls.
Keywords:
Oral submucous fibrosis; DNA damage; comet assay; gingival epithelial cells, nitric oxide, malondialdehyde.
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Article Dates:
Received: 1 February 2018 ; Accepted: 12 March 2018; Published: 29 March 2018
How To Cite:
http://dx.doi.org/10.17812/ajsmr4106 Received : 1 February 2018 Accepted; 12March 2018 Available online : 29March 2018
