Original Research Article I Volume 4 I Issue 1 I 2017
α-Amylase and α-Glucosidase Inhibitory Activity of Physagulin-F Isolated from Physalis angulata Fruits
Sateesh Pujari and Estari Mamidala
The American Journal Science and Medical Research; 4(1); 6-10
DOI:http://dx.doi.org/10.17812/ajsmr4102
Abstract:
Type 2 diabetes is a chronic medical condition that requires regular monitoring and treatment throughout your life. Natural compounds from plant sources have been extensively used as traditional medicines from centuries. The present study was carried out to isolate and identify the putative antidiabetic compound from the Physalisangulata (PA) fruit. A compound, Physagulin-F was isolated from PA fruit extract. The isolated compound Physagulin-F (50, 75, 100, 150 mg/kg) of Physalisangulata fruit was undertaken to evaluate the inhibitory and anti-diabetic activity against α-amylase and α-glucosidase. The compound ‘Physagulin-F’ showed significant concentration dependent manner antidiabetic activity. The results of this experimental study indicate that isolated compound ‘Physagulin-F’, possess anti-diabetic effects against α-amylase and α-glucosidase enzymes.
Keywords:
Physalisangulata, Physagulin-F, anti-diabetic, Type 2 diabetes.
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Article Dates:
Received: 12 December 2017; Accepted: 21 January 2018 ; Published: 23 February 2018
How To Cite:
http://dx.doi.org/10.17812/ajsmr4102 Received : 12 December 2017 Accepted; 21 January 2018 Available online : 23 February 2018
