Original Research Article I Volume 2 I Issue 3 I 2016
Modulations in oxidative enzymes by Nardostachys jatamansi root extract against nicotine induced oxidative stres in the skeletal muscle tissue of male albino rat
K.Chennaiah, M. Jayachandrudu and J. Kamakshamma
American Journal of Science and Medical Research; 2(3); 179-185
DOI:http://dx.doi.org/10.17812/ajsmr125
Abstract:
Nardostachys jatamansi (Family:Valerianaceae) is a perennial herb found in Alpine Himalayas. N. jatamansi used for long period in various chronic diseases therapeutically. The species has very long history of use as medicine in Ayurveda. Family of Solanaseace consisting the nicotine in the number of plants. However, Nicotiana tobacco consisting more range of nicotine in the Solanaseace family. Nicotine it is harmful to the human beings. Pathogen free, wistar strain male albino rats were used in the present study. Wistar strain male albino rats were used in the present study. Rats were divided into 4 groups of six in each group, i) Normal Control (NC) (Control rats received 0.9% saline) ; ii) Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months ); iii) Nardostachys Jatamansi extract treated (NJEt) (N.Jatamansi extract 50mg/kg body weight via orogastric tube for a period of 2 months.); IV)) Nicotine+Nardostachys Jatamansi extract treated (Nt+NJEt)) (Rats were received the nicotine as mentioned in Group II and Nardostachys Jatamansi as mentioned in Group III. The animals were sacrificed after 24 hrs after the last treatment by cervical dislocation and isolated the skeletal muscle tissue.
Keywords:
Nicotine, N.Jatamansi extract,SDH,LDH, MDH, Skeletal muscle and Male albino rat
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Article Dates:
Received: 2 June 2016; Accepted: 11 July 2016; Published: 19 July 2016
How To Cite:
K. Chennaiah, M. Jayachandrudu and J. Kamakshamma (2016). Modulations in oxidative enzymes by Nardostachys jatamansi root extract against nicotine induced oxidative stress in the skeletal muscle tissue of male albino rat. The Ame J Sci & Med Res, 1(2):179-185
