Original Research Article I Volume 1 I Issue 1 I 2015
lnhibition of croton oil-induced inflammatory and tumor promoting activity in mice skin by henna (Lawsonia inermis)
Mohamed H. Shwaireb
American Journal of Science and Medical Research; 1(1); 16-22
DOI:http://dx.doi.org/10.17812/ajsmr2015113a
Abstract:
Henna (Lawsonia inermis) inhibited inflammatory responses triggered by croton oil in mice ears and skin. Topical application of 0.5 or 1 mg henna extract (HE) to mice ears prior to application of 0.8 mg croton oil inhibited edema significantly (P < 0.02). The average weight of inflammated ear punches decreased by 64 and 87 %. Application of HE (5 or 10 mg) reduced, significantly (P < 0.05), Hyperplasia and leukocytes infiltration induced in the skin by application of croton oil (8 mg). Since tumor promotion is closely related to inflammation, the antitumor promoting activity of HE was investigated in two-stage model of skin carcinogenesis in mice
Keywords:
Henna (Lawsonia inermis), anti-inflammation, anti-tumor promotion, edema, papilloma
References:
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Article Dates:
Received: 2 January, 2015; Accepted: 15 February, 2015; Published: 21 February, 2015
How To Cite:
Mohamed H. Shwaireb (2015). lnhibition of croton oil-induced inflammatory and tumor promoting activity in mice skin by henna (Lawsonia inermis). The American Journal of Science and Medical Research, 1(1); 16-22. http://dx.doi.org/ 10.17812/ajsmr2015113a
